Bin Zhou, M.D., Ph.D.

Zhou, B.*, Wu, B., Tompkins, K.L., Boyer, K.L., Grindley, J.C., and Baldwin, H.S. Characterization of NFATc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development 132:1137-1146. 2005. PMID: 15689382 *Corresponding author

Chen J-W., Zhou, B.*, Shin, J., Schneider, M.D. H., BaldwinH.S., and Bergelson, J.M. Cardiomyocyte-Specific expression of the coxsackievirus and adenovirus receptor is essential for normal left ventricular development. Circ Res. 98:923-30. 2006. PMID: 16543498 *Co-first author

Wu, H., Kao, S-C., Barrientos, T., Baldwin, H.S., Olson, E.N., Crabtree, G.R., Zhou, B. and Chang, C-P. DSCR1 is a transcriptional target of NFATc1 within the endocardium during heart development. J. Biol. Chem. 282:30673-9, 2007. PMCID: 2366997

Langworthy, M., Zhou, B., de Caestecker, M., Moeckel G., and Baldwin, H.S. NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors J. Am. Soc. Nephrol. 20:311-21. 2009. PMCID: 2637056

Ying, L., Lau, A, Alvira, C.M., West R., Cann G.M., Zhou, B., Kinnear, C., Jan, E., Sarnow, P., Van de Rijn, M., and Rabinovitch, M. LC3 Mediated Fibronectin mRNA Translation Induces Fibrosarcoma Growthby Increasing Connective Tissue Growth Factor. J. Cell Sci. 122:1441-5, 2009. PMCID: 2672968

Zhou, B., Ma, Q., Kong, S.W., Hu, Y., Campbell, P.H., McGowan, F.X., Ackerman, K.G., Wu, B., Zhou, B., Tevosian S.G., and Pu, W.T. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J. Clin. Invest. 119(6):1462-76, 2009. PMCID: 2689123

ZeiniM., HangC-T, Lehrer-Graiwer, J., Zhou, B., and Chang C-P. Endothelial calcineurin-NFAT signaling functions within a narrow developmental window to regulate coronary vascular patterning. Development136:3335-45,2009

Wu, B., Zhou, B., Wang, Y., Cheng H-L, Hang^,C.T., Pu, W.T., Chang, C-P and Zhou, B. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis 48:63-72, 2010. PMID: 20014345

Hang, C.T., Yang, J., Han, P., Cheng, H.L., Shang, C., Ashley, E., Zhou, B., Chang, C-P. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466:62-7, 2010. PMCID: 2898892

Wu, B., Wang, Y., Lui, W., Langworthy, M., Tompkins, K.L., Hatzopoulos, A.K., Baldwin, H.S., Zhou, B. Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation. Circ. Res. 109:183-192, 2011 NIHMSID: 299095. PMID: 21591072

Wu, B., Zhang, Z.,Lui, W., Chen, X., Moreno-Rodriquez, R.A.,Wang, Y.,Chamberlain, A., Markwald, R.A., O’Rourke B., Sharp, D. J., Lenz, J., Baldwin, H.S.,Chang, C.P. and Zhou, B. Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial to Endocardial VEGF Signaling. Cell. 151(5):1083-1096, 2012

Wang, Y, Wu, B, Chamberlain, AA, Lui, W, Koirala, P, Susztak, K, Klein, D, Taylor, V, Zhou, B. Endocardial to myocardial Notch-Wnt-Bmp axis regulates early heart valve development. PLoS ONE 8(4):e60244, 2013

Xiong, Y, Li, W, Shang, C, Chen, R, Wu, B, Pan, P, Zhou, B, Longaker, M, Chang, C-P. Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair. Dev. Cell 25:169-181, 2013

Zhang Z, Zhou B. Accelerated Coronary Angiogenesis by Vegfr1-Knockout Endocardial Cells PLoS ONE 8(7):e70570, 2013

Chamberlain AA, Lin M, Lister RL, Maslov AA, Wang Y, Suzuki M, Wu B, Greally, JM, Zheng D, Zhou B. DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc 2014 Jun 19;3(3):e000976

Quick Links

Faculty Profile

Contact Information

Professional Interests

Selected Publications

Related News

Research Brief

Pursuing New Treatments for Heart Disease

Feature

Seeking Success Against Heart Failure

News Release

Surprise Origin for Coronary Arteries Could Speed Advances in Regenerative Medicine