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  • Aditi Shastri, M.B.B.S.

Aditi Shastri, M.B.B.S.

Aditi Shastri

Assistant Professor, Department of Medicine (Oncology)

Assistant Professor, Department of Developmental & Molecular Biology

Area of Research: acute myeloid leukemia, myelodysplastic syndromes, cancer stem cells, transcription factors, STAT3, RNA biology and therapeutic interference, health disparities

Contact Information

718.920.4826718.798.7474

Montefiore Medical Center
111 East 210th Street
Hofheimer Main, Room 100
Bronx, NY 10467

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Professional Interests

I am a board certified hematologist and medical oncologist. I specialize in caring for patients with hematologic malignancies and specifically myelodysplastic syndromes (MDS), acute myeloid leukemia (AML) and aplastic anemia (AA).

I have a strong interest in exploring novel treatment approaches for myelodysplatic syndromes (MDS) and Acute Myeloid Leukemia (AML) after the failure of therapy with hypomethylating agents. I specifically focus on therapeutically targetting the transcription factor STAT3 in MDS and AML. I am the Principal Investigator of an Investigator initiated trial (IIT) exploring STAT3 inhibition in hematologic malignancies with the STAT3 inhibitor pyrimethamine.

I am an advocate for addressing health disparities across the spectrum of cancer care and I enagage in health disparities research with the use of large clinical datasets such as the SEER and SEER-Medicare cancer registries

My research was previously funded through the NIH Paul Calabresi Career Development Award (K12) & currently through the Leukemia Lymphoma Society (LLS)-TRP Award.

My original research and reviews have been published in leading peer reviewed journals that include Blood, Nature Reviews Cancer & Lancet Hematology.  I have been an invited speaker at several conferences and forums nationally as well as internationally.


Selected Publications

 

       1.      Abbasi A, Peeke S, Shah N, Mustafa J, Khatun F, Lombardo A, Abreu M, Elkind R, Fehn K,    de    Castro A, Wang Y, Derman O, Nelson R, Uehlinger J, Gritsman K, Sica RA, Kornblum N, Mantzaris I, Shastri A, Janakiram M, Goldfinger M, Verma A, Braunschweig I, Bachier-Rodriguez L. Axicabtagene ciloleucel CD19 CAR-T cell therapy results in high rates of systemic and neurologic remissions in ten patients with refractory large B cell lymphoma including two with HIV and viral hepatitis. J Hematol Oncol. 2020 Jan. PMID: 31900191

2.      Adrianzen Herrera D, Pradhan K, Snyder R, Karanth S, Janakiram M, Mantzaris I, Braunschweig I, Budhathoki A, Shah UA, Verma AK, Murthy SB, Shastri A. Myelodysplastic syndromes and the risk of cardiovascular disease in older adults: A SEER-medicare analysis. Leukemia. 2019 Dec 16. PMID : 31844145

3.      Sridharan A, Schinke CD, Georgiev G, Da Silva Ferreira M, Thiruthuvanathan V, MacArthur I, Bhagat TD, Choudhary GS, Aluri S, Chen J, Pradhan K, Xia Y, Panjikaran M, Sims G, Bhagat CK, Bender R, Keeler L, Graber A, Heuck C, Fletcher FA, Alapat D, Weinhold N, Johnson SK, Wickrema A, Barlogie B, Morgan GJ, Shastri A, Steidl U, Will B, Verma A. Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias. Blood Adv. 2019 Dec 10; PMID : 31805192

4.      Shah UA, Shah N, Qiao B, Acuna-Villaorduna A, Pradhan K, Adrianzen Herrera D, Sica RA, Shastri A, Mantzaris I, Derman O, Kornblum N, Braunschweig I, Ye BH, Verma A, Janakiram M.Cancer. Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States. 2020 Feb 1. PMID : 31769871

5.       Bowler TG, Pradhan K, Kong Y, Bartenstein M, Morrone KA, Sridharan A, Kessel RM, Shastri A, Giricz O, Bhagat TD, Gordon-Mitchell S, Rohanizadegan M, Hooda L, Datt I, Przychodzen BP, Parmar S, Maqbool S, Maciejewski JP, Steidl U, Greally JM, Verma A. Leuk Lymphoma. Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions2019 Dec. PMID : PMID: 31288594

6.      Kaner JD, Thibaud S, Jasra S, Wang Y, Janakiram M, Sharma A, Sridharan A, Elias H, Polineni R, Assal A, Weiss L, Braunschweig I, Steidl U, Pradhan K, Shastri A, Chaitowitz M, Zingman B, Will B, Mantzaris I, Verma A. HIV portends a poor prognosis in myelodysplastic syndromes. Leuk Lymphoma. 2019 Dec. PMID : 31282240

7.      Adrianzen Herrera D, Kornblum N, Acuna-Villaorduna A, Sica RA, Shah U, Butler M, Vishnuvardhan N, Shah N, Bachier-Rodriguez L, Derman O, Shastri A, Mantzaris I, Verma AK, Braunschweig I, Janakiram M. Barriers to Allogeneic Hematopoietic Stem Cell Transplantation for Human T Cell Lymphotropic Virus 1-Associated Adult T Cell Lymphoma-Leukemia in the United States: Experience from a Large Cohort in a Major Tertiary Center. Biol Blood Marrow Transplant. Feb 2019. PMID : 30769194

8.      Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S,  Lopez R, Pradhan K, Giricz O, Ravipati G, Wong L, Cole S, Bhagat T, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan V, Wickrema A, Ye H, Frank D, Pellagatti A, Boultwood J, Zhou T, Kim Y, MacLeod R,Epling-Burnette PK, Ye M, McCoon P, Woessner R, Steidl U, Will B and Verma A. Antisense STAT3 Inhibitor Decreases Viability of Myelodysplastic and Leukemic Stem Cells. Journal of Clinical Investigation, Dec 2018, PMID : 30252677

9.         Kao YR, Chen J, Narayanagari SR, Todorova TI, Aivalioti MM, Ferreira M, Ramos PM, Pallaud C, Mantzaris I, Shastri A, Bussel JB, Verma A, Steidl U, Will B. Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag. Science Translational Medicine. Sept 2018. PMID : 30209246

10.   Shah UA, Chung EY, Giricz O, Pradhan K, Kataoka K, Gordon-Mitchell S, Bhagat TD, Mai Y, Wei Y, Ishida E, Choudhary GS, Joseph A, Rice R, Gitego N, Parrish C, Bartenstein M, Goel S, Mantzaris I, Shastri A, Derman O, Binder A, Gritsman K, Kornblum N, Braunschweig I, Bhagat C, Hall J, Graber A, Ratner L, Wang Y, Ogawa S, Verma A, Ye BH, Janakiram M. North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies. Blood, Aug 2018, PMID: 30104217

11.   Adrianzen Herrera D, Ayyappan S, Jasra S, Kornblum N, Derman O, Shastri A, Mantzaris I, Verma A, Braunschweig I, Janakiram M. Characteristics and outcomes of progressive multifocal leukoencephalopathy in hematologic malignancies and stem cell transplant - a case series. Leukemia Lymphoma, July 2018, PMID: 29969336

12.   Snyder R, Libby T, Raciti P, Amin B, Jacobson M, Rakheja D, Fleming K, Bartenstein M, Zhu C, Goel S, Verma AK, Shastri A. Myelodysplastic Syndrome and Sweets Syndrome Are Associated with a Mutation in Isocitrate Dehydrogenase 1. Anticancer Research. April 2018, PMID : 29599340

13.   Shastri A; Verma A; Eltrombopag reduces clinically relevant thrombocytopenic events in higher risk MDS and AML. Lancet Haematology Commentary. Jan 2018, PMID : 29241763

14.   Kanna S; Choudhary G; Ramachandran N; Steidl U; Verma AK; Shastri A. STAT3 inhibition as a therapeutic strategy for leukemia. Leuk Lymphoma. 2017 Nov 22. PMID : 29164994

15.   Darbinyan K*; Shastri, A*; Budhathoki, A*; Helbig, D; Pradhan K et all. Hispanic Ethnicity is Associated with Younger Age at Presentation and Worse Survival in Acute Myeloid Leukemia. Blood Advances. * Equally Contributed

16.   Shastri A; Mantaris I; Yu Y; Janakiram M; Verma A; Barta SK. Sites of Extranodal Invovlement Are Prognostic I n Patients with Stage 1 Follicular Lymphoma: An Analysis of the Surveillance, Epidemiology and End Results Database. Oncotarget. 2017 Jul 14. PMID: 29108238

17.   Shastri A; Budhathoki A; Barta S; Kornblum N; Derman O; Battini R; Raghupathy R; Verma A; Frenette P; Braunschweig I; Janakiram M. Stimulation of Adrenergic Activity by Desipramine Enhances Hematopoietic Stem and Progenitor Cell Mobilization along with G-CSF in Multiple Myeloma. Am J Hematol. 2017 Jul 4. PMID: 28675459

18.   Shastri A; Will B; Steidl U; Verma A. Stem Cell Alterations In Myelodysplastic Syndromes. Blood, 2017 Feb, PMID: 28159737

19.   Bowler TG; Bartenstein M; Morrone K; Shridharan A; Kessel R; Shastri A; Giricz O; Maciejeweski J; Steidl U; Verma A.Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions. Submitted for Publication

20.   Murthy SB, Shastri A, Merkler AE, Hanley DF, Ziai WC, Fink ME, Iadecola C, Kamel H, Navi BB. Intracerebral Hemorrhage Outcomes in Patients with Systemic Cancer. J Stroke Cerebrovasc Dis. 2016 Aug 25. PMID: 27569708

21.   Goel S, Hall J, Pradhan K, Hirsch C, Przychodzen B, Shastri A, Mantzaris I, Janakiram M, Battini R, Kornblum N, Derman O, Gritsman K, Al-Hafidh J, Wang Y, Halmos B, Steidl U, Maciejewski JP, Braunschweig I, Verma A. High prevalence and allele burden-independent prognostic importance of p53 mutations in an inner-city MDS/AML cohort. Leukemia. 2016 Aug;30. PMID :27125205

22.   Zell M, Assal A, Derman O, Kornblum N, Battini R, Wang Y, Narasimhulu DM, Mantzaris I, Shastri A, Verma A, Ye H, Braunschweig I, Janakiram M. Adult T-Cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy. Oncotarget. 2016 Jun 22. PMID:27341021

23.   Bachegowda L, Morrone K, Winski SL, Mantzaris I, Bartenstein M, Ramachandra N, Giricz O, Sukrithan V, Nwankwo G, Shahnaz S, Bhagat TD, Bhattacharyya S, Assal A, Shastri A, Gordon-Mitchell S, Pellagatti A, Boultwood J, Schinke C, Yu Y, Guha C, Rizzi J, Garrus J, Brown S, Wollenberg L, Hogeland G, Wright D, Munson M, Rodriguez M, Gross S, Chantry D, Zou Y, Platanias LC, Burgess LE, Pradhan K, Steidl U, Verma A. Pexmetinib : A Novel Dual Inhibitor of Tie2 and p38MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes & Acute Myeloid Leukemia. Cancer Res. 2016 Aug 15. PMID : 27287719

24.   Assal A, Dong B, Khan H, Medavarapu R, Shastri A, Pradhan K, Friedman E, Mantzaris I, Janakiram M, Battini R, Kornblum N, Yu Y, Verma A, Braunschweig I, Derman O. Analysis of chronic myelogenous leukemia in an underserved, inner-city cohort shows a significant five year overall survival that is not affected by choice of tyrosine kinase inhibitor. Leuk Lymphoma. 2016 Feb 17:1-4. PMID:26886689

25.   Shastri A, Msaouel P, Montagna C, White S, Delio M, Patel K, Alexis K, Strakhan M, Elrafei T, Reed LJ. Primary hepatic small cell carcinoma: two case reports, molecular characterization and a pooled analysis of known clinical data. Anticancer Res. 2016 Jan, PMID: 26722053

26.   Schinke, C, Giricz O, Li W, Shastri A, Gordon S, Barreyro L, Bhagat T, Bhattacharya S, Will B, Steidl U, Verma A. IL-8/CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells, Blood, 2015 Mar, PMID: 25810490

27.   Shastri A, Shastri SS. Cancer screening and prevention in low-resource environments.
Nature Reviews Cancer, 2014 Dec; PMID: 25355377

28.   Daver N,* Shastri A,* Kadia T, Quintas-Cardama A, Pemmaraju N, Jabbour E, Konopleva M, O’Brien S, Pierce S, Cortes J, Kantarjan H, Verstovsek S. Phase II study of pomalidomide in combination with prednisone in patients with myelofibrosis and significant anemia.
Leukemia Research 2014 Jul, PMID: 25047979 * Equally Contributed

29.   Shusterman M, Bloomgarden NA, Sotardi ST, Shastri A. Tumor Lysis Syndrome in an Unusual Metastatic Pancreatic Neuroendocrine Tumor with Ectopic ACTH Secretion. J Gastrointest Cancer. 2015 Aug 14, PMID : 26271662

30.   Murthy SB, Moradiya Y, Shah S, Shastri A, Bershad E, Suarez JI. In-hospital Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with Primary Brain Tumors. Journal of Clinical Neuroscience. 2014. PMID : 25564270

31.   Murthy SB, Karanth S, Shah S, Shastri A, Venkatasubba Rao CP, Bershad E, Suarez JI. Thrombolysis for Acute Ischemic Stroke in Patients with Cancer: A Population Study. Stroke. 2013 Dec; PMID : 2406571

32.   Daver N, Shastri A, Kadia T, Quintas-Cardama A, Jabbour E, Konopleva M, O'Brien S, Pierce S, Zhou L, Cortes J, Kantarjian H, Verstovsek S. Modest activity of pomalidomide in patients with myelofibrosis and significant anemia. Leukemia Research. 2013 Jul 24, PMID: 23890523

33.   Cooperman,N; Shastri JS; Shastri, A; Schoenbaum, E; HIV Prevalence, Risk Behavior, Knowledge and Beliefs among Women Seeking Care at a Sexually Transmitted Infection Clinic in Mumbai, India. Health Care Women Int. 2013 Mar 4, PMID: 23659311

34.   Shastri A, Daver NG, Hayes TG. Primary Gastric Chorioadenocarcinoma: A case report and review of literature. Rare Tumors. 2011 Apr 4;3(2):e19, PMID: 21769318

 

Related News

  • Slower Clearance of Coronavirus Infection May Explain Why Men Fare Worse Than Women
    News Release
    Slower Clearance of Coronavirus Infection May Explain Why Men Fare Worse Than Women

    Apr 17, 2020

In the News

  • Why Are More Male Coronavirus Patients Dying

    Los Angeles Times - April 18, 2020

    Aditi Shastri, M.B.B.S., discusses her study that for the first time showed that men clear the novel coronavirus from their bodies slower than women. Dr. Shastri is assistant professor of medicine at Einstein and a clinical oncologist at the Montefiore Einstein Center for Cancer Care.

    Additional coverage on Dr. Shastri on COVID-19 includes: Spectrum/NY1, New York Post, Daily Mail (U.K.), and Bronx Times

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