Selected References:
Wang J.Y.J and Edelmann W. 2006. Mismatch Repair Proteins as Sensors of Alkylation DNA Damage. Cancer Cell. 6:417-418.
Schätzlein S., Ju Z., Stepczynska A., Reddy K., Saal N., Lechel A., Roychoudhury A., Kuhnel F., Schirmacher P., Wei K., Edelmann W. and Rudolph K.L. 2007. Exo1 deletion prevents DNA damage signalling and prolongs lifespan of telomere dysfunctional mice without accelerating cancer formation. Cell. 130:863-877.
Takedo M.M. & Edelmann W. 2009. Mouse models of colorectal cancer. Gastroenterology. 136:780-798. PMID: 19263594
Kucherlapati M.H., Lee K., Nguyen A.A., Clark A.B., Hou H. Jr.,Rosulek A.,Li H., Yang K., Fan K., Lipkin M., Bronson R.T., Jelicks L., Kunkel T.A., Kucherlapati R. and Edelmann W. 2010. An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anti-cancer Agents. Gastroenterology. 138:993-1002.
van Oers J.M., Roa S., Werling U., Liu Y., Genschel J., Hou H. Jr., Sellers R.S., Modrich P., Scharff M.D., Edelmann W. 2010. PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proc Natl Acad Sci U S A. 107:13384-13389.
Schaetzlein S., Chahwan R., Roa S., Avdievich E., Wei K., Eoff R.L., Sellers R.S., Clark A.B., Kunkel T.A., Scharff M., Edelmann W. 2013. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in important biological processes. Proc Natl Acad Sci U S A. 110:E2470-2479.
van Oers J.M.M., Edwards Y., Chahwan R., Zhang W., Smith C., Pechuan J., Schaetzlein S., Jin B., Wang Y., Bergman A., Scharff M.D., Edelmann W. 2013. The MutSb complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double strand break repair and mismatch repair. Oncogene, in press.